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Transplantation assays As described 30,31,32 , for noncompetitive transplantation, 1 million bone-marrow cells were retro-orbitally injected into lethally irradiated (950 cGy) B6.SJL recipient mice

Leucine is converted to glutamine, isoleucine and valine are converted to threonine, and phenylalanine is converted to tyrosine

The goal is triggering the right cellular response, not flooding the system with excess peptide

This linker design exemplifies the advantages of pH-sensitive hydrazone linkers in ADCsstable in plasma while rapidly cleaving inside tumor cellsenhancing the therapeutic index and reducing systemic toxicity

Schultz et al., 1991) and CprK-DNA (Levy et al., 2008) complexes (Fig