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Involvement of nuclear factor B (NF-B) signaling pathway in regulation of cardiac G protein-coupled receptor kinase 5 (GRK5) expression

The nucleoprotein of influenza A virus induces p53 signaling and apoptosis via attenuation of host ubiquitin ligase RNF43

This masking protein prevents signal transduction and leads to decreased activity

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Further, immune tolerance induction (ITI) protocols to mitigate ADAs are protracted (can last months to years), highly immunosuppressive (as in the case of Pompe disease) [14], and are not always effective, with little recourse available for patients who fail ITI [15]