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doi: 10.1074/jbc.C300507200 [DOI] [PubMed] [Google Scholar] Zaki M., Thoenes M., Kawalia A., Nrnberg P., Kaiser R., Heller R., et al

However, this becomes dysfunctional in AD, further worsening the effects of oxidative stress (Dringen and Arend, 2025)

This review highlights a clear dualism: HIF-1 can exert a cytoprotective function by directly upregulating anti-ferroptotic defenses like SLC7A11 and GPX4

Decreased the levels of Nrf2 and collagen II amd increased the expression level of MMP13

For example, the combination medicine of ferulic acid and DB significantly prevented liver damage and enhanced the anti-tumor effect of DB [13]