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In their study, high-dose anti-VEGFR2 treatment aggravated intratumoral hypoxia and restrained the infiltration of CD8 + T cells into the TME, thereby suppressing anti-cancer immunity
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In addition, miR-17-5p and miR-20a- 5p, which were found to be under-expressed in the low motile fraction of semen, targets PTEN and STAT signaling pathways to trigger apoptosis ( The spermatozoal miRNA have also been shown to differ in gonadotoxicity, heat stress, and impaired spermatogenesis
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