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No: HR-POK-007), were acclimated for 5 days and randomly assigned to the experiments (6 animals at least per each experimental group and interval), all of which were approved by the Local Ethics Committee

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Later, the neuroprotective effects of 7,8-DHF in a transgenic ALS mouse model SOD1 G93A were evaluated, demonstrating that chronic administration of 7,8-DHF significantly improved motor deficits and preserved spinal motor neurons count and dendritic spines [108]

Suzuki S et al., Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

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