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Many of these nuclear quantitative trait loci (QTLs) correspond to machinery responsible for mtDNA maintenance, which may influence heteroplasmy by directly acting on mtDNA and altering the relative replication efficiency of mtDNA molecules based on mtDNA sequence, whereas several others correspond to genes never before linked to mtDNA biology

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Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage