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In this article, we will make a short review of LDL metabolism, discuss the discordance between LDL-C and LDL-P, outline the atherogenic mechanisms of action of LDL by focusing on sdLDL and ox-LDL, summarize the methods used for measurement of LDL subclasses, and conclude the advances in LDL-lowering therapies using statins and PCSK9i

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doi: 10.1078/1438-4221-00294

While heterogeneity was high (I 2 =96.86%), the direction of effect consistently favored ALC across robustness checks