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In this study, using the same gene set, we analyzed pathogenic variants in both PreNAC and PostNAC samples from 76 cases in which both sets of samples were available

These locations are compatible with the enzymes functions: GS produces glutamine for the synthesis of cytoplasmic proteins and nucleotides, whereas GLS catalyses glutamine conversion to glutamate as an important step to the tricarboxylic acid cycle (TCA, also known as the Krebs cycle) entry at 2-oxoglutarate as an energy source or source of metabolic intermediates [3]

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