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Evidence indicates that fibroblastic lesions in PF patients exhibit a downregulation of sulfiredoxin-1 and nuclear factor erythroid 2-related factor 2 (Nrf2) [62]

Individuals exposed to high levels of environmental toxins

Nutrition & Food Research 59 (7), 13641372

Notably, by using a Met antagonist (ethionine) and a product of Met metabolism (SAM) in vitro , Ikeda et al

To sum up, we demonstrate that decreased intracellular level of GSH could mediate T790M-driven erlotinib resistance in NSCLC and highlight the molecular events involved (Figure 6f)
