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However, overdose remains a leading cause of acute liver failure, primarily characterized by centrilobular (zone 3) hepatic necrosis, oxidative stress, mitochondrial dysfunction, and sterile inflammation

Life Sciences, 78 (25), 29602966

Research suggests that HSCs typically constitute 5%8% of a healthy human liver, primarily regulating ECM synthesis and degradation to modulate hepatic sinusoidal blood supply (El-Serag, 2012)