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doi: 10.1038/s41467-024-53135-2 163 ZuoY

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Nicolia et al

Considering that this amino acid is essential for central nervous system (CNS) function and development ( We found a significant decline in plasma sarcosine levels in LC patients, which is also reported in critically ill COVID-19 patients ( Despite previous reports on the role of tryptophan/serotonin in anxiety and depression ( The lower arginine in LC patients as reported in acute COVID-19 (57) can be related to increased frequency of CD71+ erythroid cells (CECs) expressing arginase-I and II ( Other metabolites such as L/D-aspartate and serine amino acids are enriched in the brain and their reduction/dysfunction have been associated with neurological disorders ( Notably, a lower ATP plasma level may imply the impact of LC on the glycolytic and mitochondria pathway for cellular energy production