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Preclinical studies investigating isolation-induced psychopathology suggest that these affective changes may involve endocannabinoid system dysregulation in limbic and cortical regions highlighting the potential therapeutic value of modulating endocannabinoid tone ( Consistent with previous reports ( This study was conducted exclusively on male mice as a pilot experiment to characterize preliminary neurobehavioral outcomes before expanding the investigation to both sexes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 187.Shahnawaz M., Mukherjee A., Pritzkow S., Mendez N., Rabadia P., Liu X., Hu B., Schmeichel A., Singer W., Wu G., et al