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Optimization of orally bioavailable enhancer of zeste homolog 2 (EZH2) inhibitors using ligand and property-based design strategies: identification of development candidate (R)-5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)

10.2147/DDDT.S82972 152 PolyakK

$25 OFF YOUR FIRST TREATMENT FAQS Results may vary from person to person, but generally positive results can be seen in about 3-6 months with consistent use

PubMed Roy K, Chauhan G, Kumari P, et al