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10.1002/iub.1466 73 XiaZ.MiaoJ.ChenB.GuoJ.OuY.LiangX.et al (2022)

Ther Adv Gastroenterol

5 Conclusion In summary, lobetyolin, a chemical derived from Codonopsis pilosula , successfully interrupted the detrimental cycle of hyperandrogenism, insulin resistance, and persistent low-grade inflammation in DHEA-induced mice with PCOS

On the other hand heme can activate defense mechanisms to establish tolerance and to foster survival of the host in diverse pathological conditions via the induction of the HO-1/FT system (17, 23, 29, 30)
To eliminate GSH-conjugated toxins, GSH is exported from cells, primarily by members of the ATP binding cassette subfamily C member (ABCC, also known as MRP) family 25