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The amplification of GAA trinucleotides in the FRDA gene is closely related to the accumulation of iron in mitochondria

Although the pathophysiological mechanism of the adverse effects of homoarginine deficit has not been elucidated, homoarginine supplementation has been investigated as a strategy to influence the development of cardiovascular diseases [72,73,75,76]

10.1016/j.biopsych.2008.05.006 37 CucinottaF.RicciardelloA.TurrizianiL.ManciniA.KellerR.SaccoR.et al (2022)

Network pharmacology enhances the precision of drug discovery by linking pharmacological targets to disease mechanisms through target prediction algorithms and functional enrichment analyses, such as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway mapping (Singh et al., 2022)

Arkray, Inc., Kyoto, Japan), following which the blood samples were centrifuged at 3,500 rpm for 15 min at 4C to collect plasma
