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While significant challenges remain, the convergence of advanced molecular tools, improved animal models, and innovative clinical trial designs holds considerable promise for developing effective microglia-targeted therapies in the coming years

Validation, HG, KZ, WZ, and SW

It modulates gene expression, upregulating genes involved in tissue repair while downregulating those associated with inflammation and tissue breakdown

In this study, aiming to understand the essential role of NDRG1 in ECs in response to the potent angiogenic factor VEGF-A, we assessed the effect on angiogenesis of NDRG1 deficiency in ECs in response to VEGF-A and another potent angiogenic factor fibroblast growth factor (FGF)-2