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Two lipophilic tanshinones, cryptotanshinone and dihydrotanshinone, also inhibit the growth of apoptosis-resistant colon cancer cells by inducing autophagic cell death and p53 -independent cytotoxicity [78]

Peer review Peer review information Nature Aging thanks Juan Tena and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

In turn, in a lung cancer model, treatment with imatinib resulted in downregulation of VEGF expression in A549 tumors, which was accompanied by upregulation of p53 expression (31)

Investigating the interaction between AX supplementation and lifestyle interventionssuch as exercise or different types of dietsmay also help to identify synergistic strategies to enhance mitochondrial function

The modulation of immune responses through vitamin D's effects on the innate and adaptive immune systems has made it a key factor in the regulation of periodontal health