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These major factors include increased craving in SZ, modulating negative symptoms, pro-cognitive effects of nicotine, and genetic factors ( It has been proposed that due to the pathophysiology of SZ, these individuals may have an enhanced experience of the reinforcing effects of nicotine ( There appears to be a link between the enhanced reinforcing effects of nicotine and the role that negative affect has on increasing the smoking rate in SZ

Nicotine oral inhaler (e.g., Nicotrol inhalation) The delivery device is like a cigarette holder

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