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Description
GLP-1 receptor (GLP-1R) is expressed in pancreatic islets as well as in several extra-pancreatic organs or cell lineages, indicating that GLP-1-based drugs can exert extra-pancreatic functions

Nature 561 , 492497 (2018)
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Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV

The absorption rate through the sublingual mucosa varies greatly between individuals, meaning the actual amount of semaglutide entering the bloodstream is highly uncertain