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While theres no real health risk to simply stopping the medication, titrating can be beneficial for many patients
Going slow allows doctors to watch for symptoms and catch problems early
Interestingly, these ERR -null mice also display reduced muscle oxidative capacity, an effect that is also induced by C29, a synthetic ERR inverse agonist (Patch et al., 2011) These contradictory effects, at least in terms of a potential treatment of metabolic diseases, are also aggravated by the potential for an ERR inverse agonist to induce heart failure (Huss et al., 2007)

Molecular Carcinogenesis, 54 (10), 1096-1109

Color changes in either lyophilized powder or reconstituted solution suggest chemical degradation
