tirzepatide 1 month before and after Tirzepatide Weight Loss Journey: Our Transformative Experience Month 4 Weigh-In Update on

No food intake was allowed for at least 4 h prior to the standardised pre-dose meal (treatment arms: 2 h30 min, 4 h30 min, 6 h30 min, and 2 hnight) (Fig

Survival: survival analysis

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The STAMPEDE (Surgical Therapy and Medications Potentially Eradicate Diabetes Efficiently) trial showed that metabolic surgery, when compared with intensive medical therapy (lifestyle counseling, weight management, self-monitoring of glucose, drug therapy), significantly improved outcomes for weight loss, DM remission, glycemic control, need for DM medications, lipid and BP medications, and QoL 777 Five-year outcomes from a 2020 RCT reported that Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding achieved remission of T2D in 30% and 19% of persons, respectively, compared with 0% of controls undergoing intensive lifestyle weight intervention

As we did not observe any discontinuation of treatment during the study period, it remains unclear whether pwIIH successfully treated with GLP-1-RAs sustain their weight loss, or a yo-yo effect occurs [44], which would pose an increased risk for a disease relapse