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5 WARNINGS AND PRECAUTIONS Directions And Dosage 2 DOSAGE AND ADMINISTRATION 3 DOSAGE FORMS AND STRENGTHS Injection: clear, colorless solution available as follows: Single-Dose Pens Dose per Injection Total Strength per Total Volume 0.25 mg 0.25 mg/0.5 mL 0.5 mg 0.5 mg/0.5 mL 1 mg 1 mg/0.5 mL 1.7 mg 1.7 mg/0.75 mL 2.4 mg 2.4 mg/0.75 mL 7.2 mg (WEGOVY HD) 7.2 mg/0.75 mL Single-Patient-Use Pen (4 doses per Pen) (WEGOVY FlexTouch) Dose per Injection Total Strength per Total Volume 2.4 mg 9.6 mg/3 mL (3.2 mg/mL) Single-Dose Syringes Dose per Injection Total Strength per Total Volume 0.25 mg 0.25 mg/0.5 mL 0.5 mg 0.5 mg/0.5 mL 1 mg 1 mg/0.5 mL 1.7 mg 1.7 mg/0.75 mL 2.4 mg 2.4 mg/0.75 mL Tablets: available as: Tablet Strength Description 1.5 mg White to light yellow, round shaped debossed with 1.5 on one side and novo on the other side 4 mg White to light yellow, round shaped debossed with 4 on one side and novo on the other side 9 mg White to light yellow, round shaped debossed with 9 on one side and novo on the other side 25 mg White to light yellow, oval shaped debossed with 25 on one side and novo on the other side 10 OVERDOSAGE Overdoses have been reported with other GLP-1 receptor agonists

Of the nineteen articles included in this review, seven were from England or the United Kingdom [9,21,22,23,34,35,36], one was from Japan [24], two were from Singapore [26,27], one was from the Netherlands [29], one was from France [28], two were from China [25,30], two were from the United States [17,33], one was multicenter [18], and two were from Denmark [31,32]

Hormones & Signaling GLP-1: released after eating Insulin: blood sugar regulation Glucagon: raises blood sugar when it drops Oxytocin: bonding, labor, social behavior Vasopressin: blood pressure and water retention Pain & Mood Endorphins: your natural painkillers, released during exercise Enkephalins: pain modulation throughout the nervous system Dynorphins: stress response and pain regulation Immune Defense Defensins: antimicrobial peptides that attack bacteria, fungi, and viruses Cathelicidins: front-line immune response in skin and lungs Digestion Cholecystokinin (CCK): signals fullness after eating Ghrelin: the hunger hormone, signals when you need to eat Secretin: regulates stomach acid and pancreatic function Cardiovascular BNP (B-type natriuretic peptide): regulates blood pressure