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GLP-1 agonists: act on the metabolism upstream by extrahepatic path The emergence of glucagon-like peptide-1 (GLP-1) agonists as a treatment option for diabetes and obesity has prompted their examination in patients with MASH 5

To make firmer conclusions, additional clinical trials designed around revealing cardiovascular benefits should be conducted

Mechanistic pathways GLP-1 receptors are expressed in multiple tissues relevant to cardiovascular and renal physiology, including the kidneys, vasculature, and nervous system

10.1038/s41588-018-0332-4 94 TangC.AhmedK.GilleA.LuS.GrneH

The 1-adrenergic receptors, found on the surface of cells, facilitate various physiological responses, including regulating vascular contraction and heart rate
