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In the inflammation substudy, researchers looked at patients in the STEP-HFpEF program with obesity-related HFpEF to determine the effect of semaglutide on HF symptoms and physical limitations in people with varying levels of inflammation at baseline

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Measurable weight loss typically becomes apparent within 2-4 weeks of consistent dosing, with accelerated results after 8-12 weeks as the body adapts to GIP and GLP-1 receptor activation

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doi: 10.1017/S2045796015000189 38 JahngJWKimJGKimHJKimBTKangDWLeeJH
