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Craig CM, Liu LF, Deacon CF, Holst JJ, McLaughlin TL

The company is evaluating another key candidate, triple-acting incretin, retatrutide (which combines GLP-1, GIP and glucagon), in type II diabetes and obesity, along with other indications like obstructive sleep apnea, knee osteoarthritis and chronic low back pain, in late-stage studies

Heres what we found: At 12 months, Omada members largely demonstrated weight maintenance (0.8% average weight change), compared to patients regaining nearly half the weight back in clinical trials

What Youll Learn The true science behind GLP-1 peptides how they interact with insulin, blood sugar, and fat metabolism

A handful of nuts here, a few just one bite moments, and youve gone from a calorie deficit and the weight loss that goes with it to a calorie excess and a weight loss plateau