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1-3 Semaglutide stimulates the pancreas to produce more insulin, reduces the amount of glucose produced by the liver and slows down the digestion of food

It is hypothesized that the slowing of gastric emptying contributes to some of the more common adverse events that occur with tirzepatide and selective GLP-1RAs (e.g., nausea, diarrhea, and vomiting), as the incidence of these events most commonly coincides with the timing of the early gastric slowing

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They stimulate GH through different pathways

MazurekTZhangLZalewskiAMannionJDDiehlJTArafatHet alHuman epicardial adipose tissue is a source of inflammatory mediators
