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These activators increase the expression of ATP-binding cassette transporter subfamily A member 1 (ABCA1) and ATP-binding cassette transporter subfamily G member 1 (ABCG1) in peritoneal macrophages, as well as scavenger receptor class B member 1 (SR-BI) and lecithin-cholesterol acyltransferase (LCAT) expression in the liver of apoE / mice, thereby reducing inflammatory cytokine production (tumor necrosis factor , monocyte chemoattractant protein-1, andinterleukin-6) and atherosclerotic plaque formation [12]

Their effect in the body varies depending on the drug used

Docherty KF et al (2025) Efficacy and safety of finerenone across the ejection fraction spectrum in heart failure with mildly reduced or preserved ejection fraction: a prespecified analysis of the FINEARTS-HF trial, (in eng)

Va de administracin, periodicidad, efecto sesgado sobre el receptor de GLP-1 y acciones de frmacos basados en GLP-1 sobre reduccin de peso, permetro de cintura, HbA1c y riesgo/reversin de diabetes DM: diabetes

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