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Whether this reflects the impact of arrestins on GIPR signaling or another fundamental difference in the mechanism of activation between these two receptors is an open question that awaits delineation in future studies

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[88].Oh KS, Kim JY, Yoon BD, Lee M, Kim H, Kim M, Seo JH, Yuk SH, Sol-gel transition of nanoparticles/polymer mixtures for sustained delivery of exenatide to treat type 2 diabetes mellitus, European Journal of Pharmaceutics and Biopharmaceutics, 88 (2014) 664669

Meta-analytic data further confirm that restoration of physiological testosterone concentrations in men with documented deficiency increases lean body mass and improves body composition parameters, although exogenous testosterone administration may also increase circulating estradiol levels through aromatization [16]