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Restarting Mounjaro at the highest dose after a gap can increase the risk of adverse effects, so this should be done with caution and under medical supervision

Its fresh contribution lies in unifying neuro-inflammatory, glial, mitochondrial, and barrier mechanisms across multiple ocular diseases, critically contextualizing clinical safety signals against mechanistic plausibility and study quality, and highlighting gaps addressed by ongoing trials (e.g

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this endpoint was included because NICE recommends that patients intensify treatment when their HbA1c exceeds 7.5%, and this endpoint is therefore highly relevant for UK clinical practice [14]

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