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Subsequent studies revealed that soluble Klotho is widely present in urine, blood and cerebrospinal fluid and participates in multiple physiological processes by regulating various intracellular signaling pathways, including insulin/IGF-1, p53 and Wnt (48,49)
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Notes: Lifestyle modifications for weight management should also be employed, including a healthy diet, regular exercise, and proper sleep
JCI Insight 2018;3:e121510.ArticlePubMedPMC 16
