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Diabetes (2012) 61(11):296779

Results Here we show that in vivo genome editing enables sustained Exendin-4 secretion from liver cells, leading to prolonged elevation of Exendin-4 levels in the bloodstream

[DOI] [PubMed] [Google Scholar] 2.Astrup A, Rossner S, Van Gaal L, et al

Future research should also focus on optimizing GLP-1RAs for CNS targeting, resolving inconsistencies in spinal cord expression, and exploring combination therapies for enhanced pain relief

This inhibition consecutively leads to post-prandial GLP-1 plasma concentrations that are elevated 2-3-fold and mediates the glucose-dependent stimulation of insulin secretion and inhibition of glucagon secretion (10, 19)