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Metformin has been reported to activate AMPK and protect human islets against lipotoxicity 16

Although more human trials are needed it provides important information about posology, route administration, and possible adverse effects [98]
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If nausea, food aversion, or persistent undereating occurs despite dose stability, report it promptly

Moving from a Monday to a Saturday injection shortens that week's interval, which means you receive your next dose only 5 days later instead of 7
