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[1] [4] This combined action results in improved glycemic control and significant weight reduction
The findings of the SURMOUNT OSA trial supported this hypothesis, showing a significant improvement in AHI, hypoxic burden and sleep quality with tirzepatide compared to placebo at 52 weeks 38

The rate and extent of glycemic deterioration depend on individual factors including baseline diabetes severity, beta-cell function, insulin resistance, and adherence to lifestyle modifications

There are a variety of reasons why people respond differently to GLP-1 medications, including demographic, body composition, health, lifestyle and environmental factors
Evolution of functional mitral regurgitation and prognosis in medically managed heart failure patients with reduced ejection fraction
