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The clinical data is clear: FDA-approved weight loss medications produce 520% total body weight loss depending on the drug

Relevant data from this trial have not yet been published

ELIXA trial included patients with recent cardiovascular event (patients with acute coronary syndrome 180 days before randomization), and although there was no benefit in MACE reduction in lixisenatide treated patients compared to placebo, results revealed cardiovascular safety of lixisenatide in this specific high risk population (38, 40)

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Sitagliptin (25 M), NVP-DPP728 (270 M), or liraglutide (1000 ng/mL) treatment significantly reduced oxidized-low-density lipoprotein-induced or PKC activator-induced protein expression of nucleotide-binding domain-like receptor with a pyrin domain 3 (NLRP3), toll-like receptor 4 (TLR4), and IL-1 in a human monocytic cell line, THP-1, by decreasing phosphorylated-protein kinase C (PKC) [64]