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The level of weight loss seen following retatrutide use approaches weight loss noted after metabolic surgery and is the greatest demonstrated from any clinical trial using AOMs to date

In a recent regulatory shift, the FDA has ended the allowance for compounding pharmacies to produce copycat versions of popular GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound)

They also faced a 50% lower risk of CV death after six months

However, the research so far is limited by short study durations and a lack of diverse participant samples, leaving long-term safety and effectiveness uncertain