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Beyond MMP inhibition, leptin-induced TIMP-1 promotes myocardial fibrosis via CD63/1-integrin signaling in cardiac fibroblasts [173]

Last but not least, by reducing the dose and avoiding systemic distribution, nasal delivery of GLP-1 drugs should alleviate gastrointestinal and other adverse events, offering a promising approach for maximizing the therapeutic effects GLP-1 drugs with potentially increased compliance and safety

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Combining a stimulant (phentermine) with a GLP-1 agonist can elevate blood pressure and heart rate unpredictably