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GLP-1 drugs are hardly some experimental medicine

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Alcohol-related deaths primarily involve non-communicable diseases such as cardiovascular disease and cancer, while opioids, amphetamines, and cocaine were the most lethal among psychoactive substances

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Depending on the route of administration (and the GLP-1R agonist used), peripherally administered GLP-1 analogs seem either to act directly in the hypothalamus and hindbrain, both areas with incomplete BBB, or else on vagal afferents to transmit the signal to the hindbrain which then projects to other key feeding areas in the brain