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Genetic biomarkersparticularly GLP1R and GIPR variantsmay help contextualize whether a patient is likely to benefit from dual-agonist strategies like tirzepatide or GLP-Squared, supporting more targeted provider conversations

Clinical evidence shows an average weight loss of 15 to 20 percent over 72 weeks, meaning for someone weighing 250 pounds, this could translate to a 37 to 50-pound weight reduction
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Patients should discontinue Rybelsus immediately if pancreatitis is suspected and should not resume treatment if confirmed
