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What are the indications and contraindications for glucagon-like peptide-1 (GLP-1) receptor agonists (e.g., liraglutide (Saxenda), semaglutide (Wegovy), tirzepatide) for weight loss in adults?

Epidemiological studies have also demonstrated that the use of metformin in individuals with type 2 diabetes is associated with a lower risk of PD [26]

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Finally, ignoring persistent injection-site reactions such as ongoing redness, swelling, hardness, or painis a mistake that may indicate infection, allergic reaction, or technique problems

Current guidelines recommend GLP-1s for adults with obesity (BMI at or above 30), or adults with overweight (BMI at or above 27) plus a weight-related comorbidity such as type 2 diabetes, hypertension, fatty liver disease, or sleep apnea, for whom the cardiometabolic benefit of the medication exceeds its risks