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The Authors reported that treatment with incretins significantly suppressed the FSH-induced synthesis of progesterone through the inhibition of the expression of progestogenic factors and enzymes, whereas there was no significant effect on oestrogen synthesis by rat granulosa cells, thus suggesting the possible role of GLP-1 RA in the treatment of dysregulated steroidogenesis in PCOS [43]

This shift reflects a more mature interpretation of the evidence: the risk is not uniform across all GLP-1 users

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DeFronzo RA, Davidson JA, Del Prato S