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This was relaxed in 2016 to allow metformin use to a GFR 30, but still not allowing initiation below 45, and insisting on stopping at GFR 30

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A clinical trial in 2015 linked an undisclosed GLP-1 to significant improvements in OSA severity, while a 2016 clinical trial found that weight loss resulting from liraglutide was significantly associated with a reduction in the apnea-hypopnea index (AHI)

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