gip/glp-1 agonist Glucagon-like peptide-1 (GLP-1) receptor agonists are incretin analogues that promote glucose-mediated insulin release and are used to treat type 2 diabetes mellitus and #obesity. GLP-1 receptor agonists and GLP-1 and glucose-dependent insulinotropic Major physiological roles of GLP-1

[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC

GLP-1R Agonist Therapy for Diabetes: Benefits and Potential Risks

The Impact of Tirzepatide on Aortic Inflammation and Atherosclerosis Development To further strengthen the positive impact tirzepatide has on the heart, namely, atherosclerosis reduction [22], a study was conducted on mice involving GIPR and its impact on the cardiovascular system [23]

GLP-1RAs have demonstrated optimal clinical efficacy when administered as a therapeutic intervention during the early stages of tumor development [36]

Some case reports show that GLP-1RA treatment initiation in patients leads to worsened Pso lesions, possibly because the drug triggers immune dysregulation, which results in increased pro-inflammatory pathways [19,65]