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Liraglutide (daily) is an established shorter-acting option
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In addition, changes in microbial metabolism influence bile acid signaling and the production of short-chain fatty acids, further modulating lipid metabolism, insulin resistance, and inflammatory pathways [1]
Realworld studies demonstrate high discontinuation rates of GLP1RAs by up to 75% within the first year of use, predominantly driven by side effects 20-22
