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Retatrutide is not FDA approved (April 2026)

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All interventions were compared with current use of SGLT2is (20% of the total population) and GLP-1 RAs (5% of the total population)

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Various GLP-1RAs have been demonstrated to have significant benefits in in vitro and in vivo models of neurodegenerative diseases through modulating a variety of pathogenic mechanisms, including neuroinflammation, autophagy, mitochondrial dysfunction, and the abnormal phosphorylation of pathognomonic proteins

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