comparing cardiovascular and kidney outcomes with tirzepatide vs. glp-1 agonists Comparative effectiveness of versus receptor on cardiovascular–kidney–metabolic stage progression: a real-world cohort study SGLT2 vs GLP-1: Individualizing Diabetes,
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Persistent hyperglycemia can mediate hypoxic or ischemic injury, as well as elicit cardiomyocyte contractile dysfunction and the NF-B signaling pathway activation, thus inducing ER stress [152]
The receptor belongs to the G-protein coupled 7 transmembrane domain family and has 40% homology to the secretin receptor
K., Bao, R
