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At 2 years, GLP-1 RA use was associated with an absolute risk increase for psoriasis of 0.05%, rising to 0.08% at 4 years
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Recent findings from studies on humans and animals demonstrate that GLP-1R agonists can also modulate the stress response via HPA axis activation but data obtained so far are ambiguous
Like many medications affecting metabolism, retatrutide may cause side effects
Glucagon signalling, classically associated with raising blood glucose, also stimulates lipolysis in adipose tissue, increases mitochondrial activity in hepatocytes, and promotes whole-body energy expenditure
