retatrutide mechanism triple agonist glp-1 gip glucagon Retatrutide—A Game Changer in Obesity Pharmacotherapy Retatrutide, a GIP, GLP-1 and

10.1111/dom.12993 83 TwarogC.FattahS.HeadeJ.MaherS.FattalE.BraydenD

Highlights Diabetic kidney disease (DKD) is one of the most common and debilitating complications of diabetes mellitus, affecting approximately 40% of people with diabetes mellitus and representing the leading global cause of end-stage kidney disease (ESKD) [1]

Rybelsus is a once-daily pill

The Krppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis

Further studies are warranted to assess the exact site of absorption and the optimal dosage for the desired action with tolerable adverse effects