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Pathophysiology of Type 2 Diabetes Mellitus

The STEP trials demonstrated that semaglutide users achieved an average of 15% body weight loss over 68 weeks compared to 2.6% with placebo

In addition, the effectiveness of a once-daily oral formulation is important as it provides an easier therapeutic option for those who may be frailer or may not have the capability for taking injections. The new findings suggest that oral semaglutide may offer added protection for high-risk patients who are managing both diabetes and heart failure

Similar results were reported by Wang et al., where GLP-1 RA treatment had a notable impact on the abundance of weight-related microbial phylotypes, though no significant change in the Firmicutes/Bacteroidetes ratio was observed (72)