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Glucagon-like peptide 1 (GLP1) analogues are licensed options for obesity, but new treatments are required to obtain better weight loss and to directly address other co-morbidities, such as non-alcoholic fatty liver disease

In those with monocular vision or prior NAION, discuss risks explicitly but do not withhold therapy solely on this basis

False negatives do happen.

Results In the intention-to-treat analysis, dementia risk was not different between GLP1-RA and DPP4i initiators (hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.871.04

quality standards, providing a safe and comprehensive approach to effective weight management and long-term metabolic health, designed to live in harmony with the body, not against it