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Tumor necrosis factor is a therapeutic target in several diseases and anti-TNF treatment is successfully applied in rheumatoid arthritis, psoriasis, ankylosing spondylitis, and IBD

Additionally, about 25% of these participants experienced a weight reduction exceeding 30% by the end of the study

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[Wadden STEP 3, JAMA 2021] STEP 5 Trial (Nature Medicine 2022) Long-term data: patients maintained an average 15.2% weight loss over 2 years of continuous semaglutide use, with sustained metabolic improvements including reduced HbA1c, blood pressure, and waist circumference

We included adults with type 2 diabetes who initiated a GLP-1 RA (exenatide [introduced in Israel in 12.2007], liraglutide [2.2010], lixisenatide [1.2015], exenatide extended-release [11.2015], dulaglutide [4.2016], and semaglutide [8.2019]) or basal insulin between February 2010 to December 2019